Search results for "Schiff base metal complexes"

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Selective G-quadruplex stabilizers: Schiff-base metal complexes with anticancer activity

2014

The affinity of three square-planar nickel(II) (1), copper(II) (2) and zinc(II) (3) Schiff-base complexes for wild-type human telomeric (h-Telo) and protooncogene c-myc G-quadruplex (G4) DNA was investigated by UV-visible absorption spectroscopy and circular dichroism. DNA-binding constants (Kb) were determined by spectrophotometric titrations for both G4-DNA and B-DNA. The results obtained point out that the three metal complexes selectively bind G4-DNA with higher affinity, up to two orders of magnitude, with respect to B-DNA. The nickel(II) complex 1 was found to be the most effective G4-DNA stabilizer and the Kb values decrease in the order 1 > 2 ≈ 3. Innovative computational investigat…

Schiff base metal complexes Nickel Copper Zinc Spectroscopy Computational Chemistry.Circular dichroismSchiff basebiologyChemistryStereochemistryGeneral Chemical Engineeringchemistry.chemical_elementBiological activityGeneral ChemistryZincG-quadruplexbiology.organism_classificationSettore CHIM/08 - Chimica FarmaceuticaMetalHeLachemistry.chemical_compoundCrystallographyG-quadruplex DNASettore CHIM/03 - Chimica Generale E InorganicaSettore BIO/10 - Biochimicavisual_artvisual_art.visual_art_mediumDNARSC Adv.

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